Acrylic Acid-d4 (CAS 285138-82-1): A Deuterated Building Block for Isotope Labeling

Acrylic acid-d4 CAS:285138-82-1 is a deuterium-labeled analog of acrylic acid in which four hydrogen atoms are replaced by deuterium. Deuterated compounds such as acrylic acid-d4 play an important role in isotope labeling, analytical chemistry, and mechanistic studies, where precise tracking of molecular transformations is required.

Due to the presence of deuterium atoms, acrylic acid-d4 exhibits similar chemical reactivity to its non-labeled counterpart while providing distinguishable signals in spectroscopic and mass-spectrometric analyses. This property makes it a valuable tool in research areas ranging from polymer science to metabolic studies.

Chemical Identity

• Chemical Name: Acrylic Acid-d4
• CAS Number: 285138-82-1
• Molecular Formula: C3H4O2
• Molecular Weight: 76.06g/mol
• Structure: Deuterium-labeled derivative of acrylic acid

The replacement of hydrogen with deuterium alters the isotopic mass without significantly affecting the molecular framework, enabling accurate analytical tracing in complex chemical systems.

Applications in Analytical and Isotope Labeling Studies

Stable Isotope Labeling

Acrylic acid-d4 is widely used as a stable isotope labeling reagent in chemical and biochemical studies. Deuterium labeling allows researchers to monitor reaction pathways, molecular transformations, and metabolic processes through analytical techniques such as mass spectrometry.

Mass Spectrometry Standards

Because of its predictable mass shift relative to unlabeled acrylic acid, acrylic acid-d4 can serve as an internal standard in quantitative analytical methods, particularly in:

• GC-MS analysis
• LC-MS quantification
• Environmental and metabolic studies

These standards help improve analytical accuracy and reproducibility.

Mechanistic Chemistry Studies

Deuterated compounds are commonly used to investigate kinetic isotope effects (KIE). By comparing reaction rates between hydrogen- and deuterium-containing molecules, researchers can gain insights into bond-breaking steps and reaction mechanisms.

Relevance in Polymer and Materials Research

As a deuterated form of acrylic acid, acrylic acid-d4 can also participate in polymerization reactions to produce deuterium-labeled polymers. Such materials are useful in:

• Polymer mechanism studies
• Surface interaction analysis
• Neutron scattering experiments
• Advanced materials characterization

The isotopic labeling enables detailed investigation of polymer structure and dynamics.

Conclusion

Acrylic acid-d4 (CAS 285138-82-1) is an important deuterated compound widely used in isotope labeling, analytical chemistry, and mechanistic research. Its ability to provide a clear isotopic signature while maintaining the chemical behavior of acrylic acid makes it a valuable reagent for studies involving reaction mechanisms, polymer science, and quantitative analytical methods.