1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) CAS:60239-18-1, also known as tetraxetan, is a macrocyclic organic chelating agent with the molecular formula C16H28N4O8. Its four nitrogen atoms and four carboxylate groups provide a strong coordination environment for a wide range of metal ions, particularly lanthanide and radioactive metal ions.
DOTA is widely utilized in radiochemistry, medical imaging, pharmaceutical research, and targeted radionuclide therapy. Its strong and stable metal-binding properties make it an important ligand for developing metal-based diagnostic and therapeutic systems.
In radiolabeling research, DOTA can coordinate radioisotopes such as 64Cu, enabling the preparation of labeled bioconjugates for imaging and biomedical studies. DOTA derivatives can also be functionalized for conjugation with biomolecules, including monoclonal antibodies, supporting the development of targeted radioimmunotherapy platforms.
Another important application is the formation of gadolinium-DOTA complexes for magnetic resonance imaging (MRI). The highly stable coordination environment provided by DOTA helps improve the suitability of gadolinium complexes for contrast-agent research.
DOTA can additionally be incorporated into peptide conjugates, where the resulting metal complexes are investigated for targeted radiopharmaceutical applications. By combining selective biomolecular targeting with stable metal chelation, DOTA-based systems provide a versatile platform for advanced diagnostic and therapeutic research.
UCHEM supplies DOTA CAS:60239-18-1 for applications in pharmaceutical research, radiochemistry, medical imaging, and advanced chelation chemistry. Contact us for product specifications, availability, packaging, and customized supply requirements.
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