tert-Butoxy-bis(dimethylamino)methane CAS:5815-08-7(Bredereck's reagent) is a useful reagent for α-methylation, α-methylenation, and α-amination of several carbonyl systems or compounds with an active CH group.
Optically active 1,10-bi-2-naphthol (BINOL, 1) and its derivatives have found many applications, ranging from chiral ligands of catalysts for asymmetric reactions to hosts for molecular recognition and enantiomer separation, to the intermediates for the synthesis of chiral materials.
Chiral C2-symmetric vicinal diamines have emerged as powerful tools for the synthesis of enantiomerically pure compounds and are now commonly used as chiral auxiliaries or ligands for a wide array of asymmetric chemical transformations, with efficiencies comparable to those obtained with the closely related 1,2-diols. (1S,2S)- 1,2-Diaminocyclohexane (also named (IS,2S)-1,2-cyclohexanediamine), together with its (1R, 2R) enantiomer, allows excellent levels of asymmetric induction in many reactions, for which it has become the ligand of choice. Its applications in asymmetric synthesis and catalysis often involves the preparation of various N,N'-substituted derivatives.
Chirality is a geometric property of some molecules and ions. A chiral molecule/ion is non-superimposable on its mirror image. The presence of an asymmetric carbon center is one of several structural features that induce chirality in organic and inorganic molecules. The term chirality is derived from the Greek word for hand.
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