2-Cyanopyrimidine CAS 14080-23-0 - Versatile Pyrimidine Intermediate for Synthesis

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Author : Nina He
Update time : 2026-04-27 18:12:58

2-Cyanopyrimidine (CAS 14080-23-0) is an important heterocyclic compound widely used as a building block in pharmaceutical, agrochemical, and fine chemical synthesis. Featuring a pyrimidine ring substituted with a cyano group at the 2-position, this compound offers high reactivity and synthetic flexibility for constructing diverse nitrogen-containing molecules.

 

Chemical Characteristics

2-Cyanopyrimidine typically appears as a white to light yellow crystalline solid. The presence of the electron-withdrawing cyano group enhances its reactivity toward nucleophilic substitution and cyclization reactions. The pyrimidine core is a key structural motif found in many biologically active compounds, making this intermediate highly valuable in medicinal chemistry.

 

Applications

Pharmaceutical Intermediates

2-Cyanopyrimidine is widely used in the synthesis of active pharmaceutical ingredients (APIs) and drug intermediates. Its structure enables the preparation of various heterocyclic compounds with potential biological activity.

 

Agrochemical Synthesis

It serves as a precursor for the development of herbicides, fungicides, and other crop protection agents.

 

Organic Synthesis

The compound is commonly used in cyclization and substitution reactions to build more complex pyrimidine derivatives and fused heterocycles.

 

Research Applications

Due to its reactivity and structural importance, it is frequently used in academic and industrial research for developing new functional molecules.

 

Related Products

5-Bromopyrimidine CAS:4595-59-9

2-Chloropyrimidine CAS:1722-12-9

2-Bromopyrimidine CAS:4595-60-2

 

These halogenated pyrimidines provide complementary reactivity for cross-coupling reactions and further functionalization, supporting a wide range of synthetic strategies.

 

Supply Advantage

2-Cyanopyrimidine (CAS 14080-23-0) and related pyrimidine derivatives are available with high purity, stable quality, and scalable supply. We support both research-scale and bulk orders with reliable delivery and consistent production.

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