3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (CAS 176969-34-9) - Fluorinated Pharma & Agro Intermediate

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Author : Nina He
Update time : 2025-12-10 17:51:15

3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (CAS 176969-34-9) is an important fluorinated heterocyclic compound widely used as an intermediate in agrochemical, pharmaceutical, and fine chemical synthesis. With a pyrazole ring substituted by a difluoromethyl group and a carboxylic acid function, the molecule provides strong electron-withdrawing properties, high stability, and excellent suitability for modern synthetic transformations.

 

This compound is best known for its role as a key building block in the development of various fungicides and bactericides. Its fluorinated structure enhances lipophilicity, metabolic resistance, and biological activity, making it valuable in designing next-generation crop protection agents. It also supports efficient synthetic routes for preparing advanced fluorinated derivatives used in industrial applications.

 

In pharmaceutical research, 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid serves as a versatile precursor for constructing bioactive small molecules. The difluoromethyl group contributes to improved pharmacokinetic properties, including permeability, binding affinity, and molecular stability. As a result, it has become an important intermediate in drug discovery and optimization programs.

 

Beyond its use in agrochemicals and pharmaceuticals, the compound finds applications in fine chemical production, specialty materials, and fluorinated intermediates. Its structural versatility makes it compatible with coupling reactions, heterocycle construction, and functional group modifications.

 

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