3',5'-Dichloro-2,2,2-trifluoroacetophenone (CAS 130336-16-2) is a highly functionalized fluorinated aromatic ketone widely used as a key intermediate in pharmaceutical, agrochemical, and fine chemical synthesis. Featuring both chlorine and trifluoromethyl substituents, the compound provides a strongly electron-withdrawing environment that enhances reactivity and enables precise structural modification in advanced organic synthesis.
This compound appears as a stable solid with strong electrophilic characteristics at the carbonyl group, making it a valuable building block for the preparation of fluorinated heterocycles, APIs, and bioactive molecules. Its unique combination of dichloro and trifluoromethyl groups contributes to high lipophilicity, increased molecular stability, and favorable performance in medicinal and industrial applications.
Applications
1. Pharmaceutical Intermediates
3',5'-Dichloro-2,2,2-trifluoroacetophenone plays an important role in the development of fluorinated pharmaceuticals. Its electron-withdrawing substituents improve metabolic stability and enhance the pharmacokinetic performance of target molecules. It is widely used in:
2. Agrochemical Development
The compound is a valuable precursor in designing high-efficiency agrochemicals, including:
The electron-deficient aromatic framework allows efficient derivatization, making it suitable for constructing potent crop-protection agents.
3. Specialty & Fine Chemicals
Due to its strong electrophilicity and structural versatility, this compound is used in:
It supports a broad range of industrial and research applications requiring fluorinated building blocks.
3',5'-Dichloro-2,2,2-trifluoroacetophenone CAS:130336-16-2 is an essential fluorinated intermediate in modern chemical synthesis. We provide high-quality material to support your pharmaceutical, agrochemical, and fine chemical development needs. Contact us for detailed specifications, pricing, and sample requests.
