4-Bromo-1-butene (CAS: 5162-44-7) is an important organic intermediate belonging to the class of alkenyl bromides. It features a four-carbon backbone with a terminal carbon–carbon double bond between the first and second carbon atoms, combined with a bromine substituent at the fourth carbon. This unique structural combination provides both high reactivity and synthetic flexibility, making the compound widely applicable in modern organic chemistry.
Due to the presence of both an alkene group and an alkyl bromide functionality, 4-Bromo-1-butene is commonly used in nucleophilic substitution reactions, alkylation processes, coupling reactions, and ring-forming strategies. It has been reported as a key reagent in the synthesis of 4-(3-butenyloxy)benzoic acid, where it serves as an efficient alkylating agent. The compound has also been employed in the total synthesis of largazole, a marine-derived natural product with notable biological activity.
Furthermore, 4-Bromo-1-butene has played a role in the double alkylation of lactams, followed by Grubbs ring-closing metathesis, enabling the construction of gymnodimine, a structurally complex marine biotoxin. In addition, it has been utilized in the preparation of dienehydrazides, demonstrating its value in building conjugated and multifunctional molecular frameworks for advanced research and development.
UCHEM can supply 4-Bromo-1-butene (CAS: 5162-44-7) with high purity and stable batch consistency, suitable for laboratory research, process optimization, and industrial production. Comprehensive technical documentation, flexible supply quantities, and reliable global logistics are available to support customer needs.
