In boron neutron capture therapy (BNCT) research and boron cluster chemistry, Sodium mercaptododecaborate (N-BSH, CAS 144885-51-8) and Mercaptoundecahydrododecaborate (BSH, CAS 12294-22-3) are two core boron cluster compounds. Sharing a twelve-boron cage structure and a thiol functional group, they complement each other in isotopic composition and application stage.
Product Positioning
N-BSH contains natural-abundance boron, making it ideal for early-stage R&D including synthetic development, formulation optimization, conjugation studies, and preliminary biological evaluation. Its chemical equivalence and cost efficiency make it a practical choice for screening and method validation. BSH, meanwhile, is one of the most widely used boron carriers in BNCT clinical research, standing alongside BPA as one of the two mainstream boron delivery agents.
Core Applications
BNCT Boron Delivery: BSH accumulates in regions of blood-brain barrier disruption via passive diffusion, with a rat plasma half-life of approximately 15 hours. This contrasts fundamentally with BPA's LAT1-mediated active transport mechanism — the two are not interchangeable. Preclinical studies show that TF-PEG liposomes encapsulating BSH can achieve selective boron accumulation in glioma cells.
Materials & Coordination Chemistry: The thiol group enables coordination with transition metals, serving as a functional ligand or precursor for boron-based coordination compounds and metal cluster materials.
Why UCHEM?
UCHEM offers N-BSH CAS:144885-51-8 and BSH CAS:12294-22-3 from stock. Strict quality control ensures batch consistency, supporting research-grade to bulk-scale requirements. Contact us for technical specifications and pricing.
