o-Carborane is a highly stable boron–carbon cluster compound with an icosahedral structure, notable for its exceptional thermal, chemical, and oxidative stability. o-Carborane (CAS 16872-09-6) and ¹⁰B-enriched o-Carborane (CAS 760207-79-2) share the same molecular structure and physicochemical properties, differing mainly in their boron isotopic composition.
The natural isotopic form of o-carborane is widely used in boron cluster chemistry, materials science, ligand design, and medicinal chemistry research. It serves as a versatile building block for synthesizing boron-containing polymers, catalysts, functional materials, and pharmaceutical intermediates.
¹⁰B-enriched o-carborane contains a high proportion of boron-10, making it essential for neutron capture applications. It is primarily applied in boron neutron capture therapy (BNCT) research, radiopharmaceutical development, and advanced nuclear medicine studies where high ¹⁰B content is required for therapeutic efficiency.
In research workflows, natural o-carborane is often used for early-stage synthesis and method development, while ¹⁰B-enriched o-carborane is applied in neutron irradiation experiments and clinically oriented studies. This staged approach ensures both cost efficiency and consistent experimental results.
