Polyethylenimine (PEI, CAS 9002-98-6) – High-Efficiency Cationic Polymer for Gene Delivery and Material Engineering

1. Product Overview

Polyethylenimine (PEI) is a water-soluble, cationic polymer with a high density of amine groups and excellent chemical reactivity. It exists in two structural forms:

• Branched PEI: Contains primary, secondary, and tertiary amines; features a highly branched 3D structure with strong buffering capacity and high gene transfection efficiency.
• Linear PEI: Composed entirely of secondary amines in a linear backbone; offers lower cytotoxicity and is widely used in in vivo gene delivery and material surface modification.

PEI is widely applied in biomedicine, nanotechnology, water treatment, specialty coatings, and advanced materials.

2. Technical Specifications

• High cationic density for effective binding with DNA, RNA, or negatively charged surfaces
• Excellent buffering capacity, ideal for endosomal escape in gene delivery
• Easy chemical modification via abundant amine groups
• Outstanding water solubility across a broad pH range
• Wide molecular weight range and flexible customization

1. Gene Delivery & Cell Transfection

PEI is a leading non-viral vector for delivering plasmid DNA, siRNA, and mRNA. Branched PEI with ~25 kDa molecular weight is often considered the “gold standard” for in vitro transfection efficiency.

2. Nanomaterial Functionalization

Used for surface modification of nanoparticles (e.g., QDs, SPIONs, CNTs) to improve dispersibility, biocompatibility, and functional targeting.

3. Water Treatment & Heavy Metal Chelation

Amine groups in PEI can chelate with heavy metal ions like Cu²⁺, Pb²⁺, Cr⁶⁺, making it effective for wastewater treatment and ion exchange resin modification.

4. Paper Making & Textile Finishing

Acts as a wet-strength agent, retention aid, or dye fixing agent in paper and textile industries, enhancing fiber bonding and dye durability.

5. Coatings & Surface Modification

PEI enables construction of multilayer films, antibacterial surfaces, or functional coatings for biosensors, flexible electronics, and smart materials.

5. Packaging & Storage

6. Ordering Information

• Multiple molecular weight ranges (600 Da – 750,000 Da)

• Linear and branched forms
• Solid or aqueous solutions
• Custom modifications and derivatives upon request

For samples, technical datasheets, or custom solutions, please contact us:

Email: uchemsales@gmail.com

Web: www.myuchem.com