Product Overview
3-Ethynylaniline (CAS: 54060-30-9) is a high-value organic intermediate featuring both an amino group and a terminal alkyne functionality. This unique dual-reactive structure makes it an indispensable building block in pharmaceutical synthesis, click chemistry, and advanced polymer materials.
EC Number: 258-944-6
Molecular Formula: C8H7N
Molecular Weight: 117.15 g/mol
Purity: ≥98% (GC)
Appearance: Clear Liquid
Key Applications
1. Pharmaceutical Intermediate
3-Ethynylaniline serves as a critical intermediate in the multi-step synthesis of erlotinib hydrochloride and icotinib – both are epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors used in non-small cell lung cancer treatment . It is also utilized in synthesizing quinazoline and nicotinic acid derivatives .
2. Click Chemistry & Organic Synthesis
As a terminal alkyne, this compound is an ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, enabling efficient construction of complex molecular architectures . This makes it valuable for drug discovery and bioconjugation applications.
3. Advanced Polymer Materials
3-Ethynylaniline is employed in the synthesis of high-performance benzoxazine monomers used in aerospace, aviation, and defense-grade composite resins . These materials offer exceptional thermal stability and mechanical properties.
4. Fluorescent Probes & Immunoassays
Derivatives of 3-Ethynylaniline are used as important fluorescent labeling agents in immunoassays and bioanalytical detection systems.
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