Valinomycin (CAS 2001-95-8) - In Stock: Properties, Applications & Ordering

Product Profile

Valinomycin CAS:2001-95-8 is a cyclic dodecadepsipeptide ionophore (C54H90N6O18, MW 1111.32) produced by Streptomyces fulvissimus. It exhibits exceptional selectivity for potassium ions (K⁺) over sodium (Na⁺) with a selectivity coefficient (K⁺/Na⁺) of approximately 10⁴:1, facilitating K⁺ diffusion across lipid bilayers at rates up to 10⁵-fold above background.

Mechanistic & Application Highlights

1. Ionophore in Membrane Transport Studies

Valinomycin acts as a mobile carrier, encapsulating K⁺ within its carbonyl-lined cavity. This property is widely exploited to collapse mitochondrial membrane potential (ΔΨm) in apoptosis and metabolic research.

2. Potassium-Selective Electrodes (ISEs)

The gold-standard ionophore for polymeric membrane K⁺-selective electrodes. Valinomycin-based sensors achieve Nernstian response (slope 59.16 mV/decade at 25°C) with detection limits in the sub-micromolar range, critical for clinical diagnostics and environmental monitoring.

3. Chiral Stationary Phase

Its asymmetric macrocyclic structure enables enantioselective recognition. Valinomycin has been successfully immobilized as an optically active stationary phase for GC, HPLC, and capillary electrophoresis, resolving racemates of amino acid derivatives and chiral drugs.

4. Bioactivity & Pharmacological Potential

• Induces caspase-dependent apoptosis in cancer cell lines (e.g., HeLa, MCF‑7).
• Inhibits F₀F₁-ATPase, uncoupling oxidative phosphorylation.
• Suppresses neuronal differentiation via Ca²⁺-dependent pathways.
• Antagonizes endothelin-1-induced vasoconstriction in vitro.
• Exhibits insecticidal and plant growth-regulating activity, suggesting agrochemical applications.

Quality & Supply

• In stock – ready for immediate dispatch
• Batch-specific COA provided with each order
• Packaging: 10 mg, 50 mg, 100 mg, 1 g, and bulk
• Custom synthesis available upon request

For research and industrial use only.