5-Bromopyrimidine (CAS: 4595-59-9): A Key Intermediate for Pharmaceutical and Agrochemical Synthesis

Views : 321
Author : Nina He
Update time : 2025-07-21 18:00:49

5-Bromopyrimidine (CAS Number: 4595-59-9) is a halogenated heterocyclic compound that serves as a valuable intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. As a brominated derivative of pyrimidine, it offers high reactivity at the 5-position, making it a preferred substrate for metal-catalyzed cross-coupling reactions such as Suzuki, Heck, and Buchwald–Hartwig.

 

Basic Information

Chemical Name: 5-Bromopyrimidine

CAS Number: 4595-59-9

Molecular Formula: C4H3BrN2

Molecular Weight: 158.98 g/mol

Appearance: off-white crystal powder

Purity: ≥98% (GC or HPLC)

 

Applications

5-Bromopyrimidine is widely used in the preparation of:

  • Pharmaceutical APIs – as a key intermediate in antiviral, anticancer, and kinase inhibitor compounds.
  • Agrochemicals – for the synthesis of herbicidal and fungicidal actives.
  • Advanced materials – as a precursor for functionalized pyrimidine-based ligands and bioactive heterocycles.

 

Due to the electron-deficient nature of the pyrimidine ring, the bromine atom at position 5 readily undergoes substitution or palladium-catalyzed coupling, enabling the construction of diverse molecular scaffolds.

 

Market & Supply

As demand for nitrogen-containing heterocycles continues to grow in pharmaceutical R&D, 5-Bromopyrimidine has gained increasing importance. UCHEM supplies high-purity 5-Bromopyrimidine with full documentation (COA, MSDS, NMR) and supports global delivery.

 

We also supply the following products

2-Chloropyrimidine CAS:1722-12-9

2-Bromopyrimidine CAS:4595-60-2

2-Cyanopyrimidine CAS:14080-23-0

 

Contact Us

For bulk inquiries, technical specifications, or sample requests of 5-Bromopyrimidine (CAS 4595-59-9), please contact UCHEM at www.myuchem.com or email uchemsales@gmail.com.

Related News
Read More >>
4,4'4,"-Tri-tert-butyl-2,2':6',2"-terpyridine (CAS 115091-29-7): A Sterically Tuned Terpyridine Ligand for Coordination Chemistry 4,4'4,"-Tri-tert-butyl-2,2':6',2"-terpyridine (CAS 115091-29-7): A Sterically Tuned Terpyridine Ligand for Coordination Chemistry
Jun .24.2026
4,4'4,"-Tri-tert-butyl-2,2':6',2"-terpyridine (CAS 115091-29-7) is a terpyridine ligand used in coordination chemistry, catalysis, and functional materials research.
3,6-Dioxaoctanedioic Acid CAS 23243-68-7 White Powder Available from Stock 3,6-Dioxaoctanedioic Acid CAS 23243-68-7 White Powder Available from Stock
Jun .23.2026
3,6-Dioxaoctanedioic Acid (CAS 23243-68-7) is a high-purity white powder dicarboxylic acid available from stock, widely used in polymer synthesis, resin modification, and specialty chemical applications.
1,1'-Bi(adamantane) CAS 3732-31-8 - High-Performance Adamantane Building Block 1,1'-Bi(adamantane) CAS 3732-31-8 - High-Performance Adamantane Building Block
Jun .23.2026
1,1'-Bi(adamantane) CAS 3732-31-8 is a high-purity adamantane-based cage hydrocarbon used as an intermediate in organic synthesis, pharmaceutical research, and advanced materials development. It offers excellent structural rigidity, thermal stability, and reliable performance for specialty chemical applications.
Betadex Sulfobutyl Ether Sodium CAS 182410-00-0: An Advanced Cyclodextrin Excipient for Drug Formulation Betadex Sulfobutyl Ether Sodium CAS 182410-00-0: An Advanced Cyclodextrin Excipient for Drug Formulation
Jun .22.2026
Betadex Sulfobutyl Ether Sodium (CAS 182410-00-0) is a modified β-cyclodextrin excipient used to improve drug solubility, stability, and bioavailability in pharmaceutical formulations.
Newsletter
Subscribe free newsletter to get latest products and discount information.
Message Us